What is lay off the shrooms?

Something that is said to somebody in jest when they make a statement that is so outrageous, it would seem that their mind has been affected by the use of the psychedelic drug.

Rob: i was listening to some slayer earlier \m/

Vince: yeah they're just alright. You know, they're okay.

Rob: You need to lay off the shrooms bro, you're trippin'. Slayer is fucking awesome!

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lay off the shrooms - video