What is famme?

A feminine version of the word fam used specifically when talking to or about a female member of the human species.

Ben: Ayyo famme wagwan
Sarah (the famme in question): Ayyo my g

famme - meme gif

Ghetto-talk, meaning "family." Also used to mean friends, or really just anyone you greet.

Yo, what's goodie in the hoodie, famm?!