Definder - what does the word mean?

What is The Seth Rogen gene?

A gene that when injected into your bloodstream gives you the appearance of being funny even though you've said nothing funny

You: So what's this one?
Doctor: The Seth Rogen gene, it gives you the appearance of being funny even though you've said nothing funny.
You: Oh... Hey doc are we done here? I gotta grab some beers with the fellas.
Doctor: HAHAHA! THAT IS HILARIOUS!

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The Seth Rogen gene - video

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