Definder - what does the word mean?

What is prepare your asshole?

An exclamation when an upcoming event or deadline is approaching that will most likely lead to hardship. This can be used synonymously with the phrase "Your gonna get raped".

Dakota - "Man, I have two test, a paper, and finals are coming up... I am going to fail out of college...."

Travis - "Well damn, you better prepare your asshole.."

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prepare your asshole - video