Definder - what does the word mean?

What is madcow disease?

A disease suffered by a fat chick who are so diguested with herself she cockblocks any guy from talking to her attractive friend(s). Fat women who suffer this disease for long periods of time will develop a permanent pissed off demeanor look on their face. They possess chubby perma-frown cheeks resembling a bulldog's jowls.

I was trying to mack on this hot chick and this fat bitch with madcow disease came over and shit all over my game.

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madcow disease - video

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