Definder - what does the word mean?

What is gets up my nose?

An expression of annoyance or disgust from the South West of England, and can be applied to just about anything from physical objects and people to ideas and opinions. It originated quite literally from something getting into the nasal passages and causing pain, irritation and aggravation. From there its use expanded to cover just about anything that causes annoyance, exasperation or discomfort. It is now used widely throughout the UK.

That twat Malcolm really gets up my nose.

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gets up my nose - video