Definder - what does the word mean?

What is castrate yourself?

Something that is said to a dude who has said or done something so inexplicably stupid that his gametes need to be immediately removed from the gene pool.

Ryan: Yeah, I thought it best to get back together with her again.
Josh: Isn't this the fourth time?
Ryan: Well, yeah.
Josh: Fucking castrate yourself.

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castrate yourself - video