Definder - what does the word mean?

What is pissed them off?

This is a phrase commonly used throughout the UK to indicate to a friend, colleague or even a total stranger that they have seriously annoyed a number of other people by word, action or attitude and that they can expect repercussions.

"Malcolm's just changed a whole load of databases that took months to set up, system support are fuming, he's really pissed them off!"

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pissed them off - video